O13 Improved early vancomycin exposure in neonates using a population pharmacokinetic model-based vancomycin dosing regimen
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چکیده
منابع مشابه
Predictive Performance of a Vancomycin Population Pharmacokinetic Model in Neonates
INTRODUCTION The pharmacokinetics of vancomycin are highly variable among neonates, which makes dosing challenging in this population. However, adequate drug exposure is critical, especially when treating methicillin-resistant Staphylococcus aureus (MRSA) infections. Utilization of population pharmacokinetic models and Bayesian methods offers the potential for developing individualized therapeu...
متن کاملA Physiologically-Based Pharmacokinetic Model for Vancomycin
A Physiologically-Based Pharmacokinetic Model for Vancomycin
متن کاملA population pharmacokinetic model for individualised dosage regimens of vancomycin in Chinese neonates and young infants
Population pharmacokinetic (PPK) modelling is an easy and impartment method for estimating drug concentration for use inindividualized therapy, especially for young patients and to help protect drug-induced diseases. The purpose of this study was to develop a PPK model for effective dosing of vancomycin in Chinese neonates and young infants. The PPK modelling tool Phoenix® NLME™ was use to asse...
متن کاملA Physiologically-Based Pharmacokinetic Model for Vancomycin by
Vancomycin is an antibiotic used for the treatment of systemic infections. It is given intravenously usually every twelve or twenty-four hours. This particular drug has a medium level of boundedness, with approximately fifty to sixty percent of the drug being free and thus physiologically effective. A physiologically-based pharmacokinetic (PBPK) model was used to better understand the absorptio...
متن کاملPopulation pharmacokinetics of vancomycin in premature Malaysian neonates: identification of predictors for dosing determination.
The present study determined the pharmacokinetic profile of vancomycin in premature Malaysian infants. A one-compartment infusion model with first-order elimination was fitted to serum vancomycin concentration data (n = 835 points) obtained retrospectively from the drug monitoring records of 116 premature newborn infants. Vancomycin concentrations were estimated by a fluorescence polarization i...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 2019
ISSN: 0003-9888,1468-2044
DOI: 10.1136/archdischild-2019-esdppp.13